|
Neurodegenerative Disorders
|
0.070 |
Biomarker
|
group |
BEFREE |
In adult rats, intrathecal implantation of encapsulated hCNTF-C2C12 cells or control C2C12 confirmed the long-term survival of these cells and their potential use as a source of neurotophic factors for the treatment of neurodegenerative diseases.
|
8934227 |
1996 |
|
Neurodegenerative Disorders
|
0.070 |
Biomarker
|
group |
BEFREE |
Together, these results indicate that rhCNTF fused with the protein transduction domain/TAT retains neurotrophic activity in the absence of CNTFs cytokine-like side effects and may be a promising candidate for the treatment of motor neuron and other neurodegenerative diseases.
|
19457136 |
2009 |
|
Neurodegenerative Disorders
|
0.070 |
Biomarker
|
group |
BEFREE |
These data suggest that CNTF originated from TRPV1 activated astrocytes may be beneficial to treat neurodegenerative disease associated with neuro-inflammation such as Parkinson's disease.
|
30423807 |
2018 |
|
Neurodegenerative Disorders
|
0.070 |
Biomarker
|
group |
LHGDN |
Ciliary neurotrophic factor null alleles are not a risk factor for Charcot-Marie-Tooth disease, hereditary neuropathy with pressure palsies and amyotrophic lateral sclerosis.
|
17651970 |
2007 |
|
Neurodegenerative Disorders
|
0.070 |
Biomarker
|
group |
BEFREE |
The mechanisms underlying CNTF-mediated neuroprotection were explored through transcriptome analysis, revealing widespread upregulation of proteolysis inhibitors, which may prevent cellular/extracellular matrix degradation and complement activation in neurodegenerative diseases.
|
25896245 |
2015 |
|
Neurodegenerative Disorders
|
0.070 |
Biomarker
|
group |
BEFREE |
Neurotrophic factors, such as ciliary neurotrophic factor (CNTF), have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), a human neurodegenerative disease primarily of upper and lower motor neurones.
|
8543936 |
1995 |
|
Neurodegenerative Disorders
|
0.070 |
Biomarker
|
group |
BEFREE |
Ciliary neurotrophic factor (CNTF) is characterized as a neuropoietic cytokine for a broad spectrum of neurons, leading to its evaluation in humans suffering from neurodegenerative diseases.
|
24486790 |
2014 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Ciliary neurotrophic factor (CNTF) has been evaluated as a candidate therapeutic agent for diabetes and its neural complications.
|
29795129 |
2018 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance.
|
9177239 |
1997 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Effects of Jinmaitong Capsule () on ciliary neurotrophic factor in sciatic nerves of diabetes mellitus rats.
|
23371458 |
2013 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
CNTF and related neuropoietic cytokines affect growth and differentiation of various neoplasms.
|
10720204 |
1999 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The mRNA for the alpha chain specific for the CNTF receptor was detected by Northern blot in tumors secreting prolactin (PRL) and GH and in non-functioning tumors.
|
11375124 |
2001 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In our RT-PCR screen for cytokine expression in human brain tumors we discovered increased levels of oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF), all belonging to the interleukin-6 (IL-6) cytokine family, in most of the tumors.
|
11494026 |
2001 |
|
Retinal Diseases
|
0.030 |
AlteredExpression
|
group |
BEFREE |
In addition, CNTF levels were decreased in serum of retinopathy of prematurity children and in retinal tissue of oxygen-induced retinopathy mice.
|
28589680 |
2017 |
|
Retinal Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
This study provides evidence for a therapeutic potential of CNTF beyond degenerative retinal disease.
|
27494343 |
2016 |
|
Retinal Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
Anti-apoptotic effects of CNTF gene transfer on photoreceptor degeneration in experimental antibody-induced retinopathy.
|
12935781 |
2003 |
|
Metabolic Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
These findings led to clinical trials to test the therapeutic potential of CNTF and CNTF derivatives for treating neurodegenerative and metabolic diseases.
|
26187860 |
2015 |
|
Metabolic Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Ciliary neurotrophic factor (CNTF) is a promising candidate for the treatment of neurodegenerative or metabolic diseases, but suffers rapid clearance in body.
|
28711730 |
2017 |
|
Neuropathy
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Impaired expression of ciliary neurotrophic factor in Charcot-Marie-Tooth type 1A neuropathy.
|
19525893 |
2009 |
|
Neuropathy
|
0.020 |
Biomarker
|
group |
BEFREE |
The mRNA levels of nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF), and interleukin-6 (IL-6) were examined in sural nerves of 22 patients with acute necrotizing vasculitic neuropathies.
|
11360269 |
2001 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
However, we did not detect expression of LIF-, IL-11-, IL-6-R and CNTF-R in prolactinomas, of CNTF in normal pituitaries and of OSM-R in ACTH-secreting adenomas.
|
11095488 |
2000 |
|
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Lastly, there were no effects of CNTF on the elevated T-maze, a behavioral test of anxiety, suggesting that a different mechanism may underlie anxiety-like behavior.
|
30299260 |
2019 |
|
Brain Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Ciliary neurotrophic factor receptor α subunit (CNTFRα) and CNTF play important roles in neuron survival, glial differentiation and brain tumor growth.
|
28765641 |
2017 |
|
CNS disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
While its therapeutic potential for CNS diseases has been clear for sometime, the blood brain barrier (BBB) hinders the systemic delivery of CNTF and direct bolus injections are not suitable due to the short half-life of CNTF.
|
16475952 |
2006 |
|
Eating Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We used a hierarchical model approach to include prior genetic knowledge of the specific and found that variants in CNTF, in its receptor CNTFR, and in NTRK2 were significantly associated with a lower age at onset of the ED.
|
20219210 |
2010 |